BioEngineering Research GroupiDrugs,12, 642-647 (2009)
Carvalho, J., Prazeres, D. M. F., Monteiro, G. A.
The progress of DNA vaccines as an immunization protocol is sustained by a growing number of vaccines being tested in clinical trials and by the recent approval of four DNA products for veterinary applications. This technology offers important therapeutic and commercial advantages over conventional approaches. However, DNA vaccine technology has still to be further optimized by the use of improved constructs, delivery systems and immunization protocols in order to achieve in clinical trials the promising results obtained in pre-clinical models.
Keywords: DNA vaccines; clinical trials; plasmid manufacture; licensed DNA vaccines
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