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The Bioseparation Engineering Laboratory (BEL) at IBB-IST-BERG aims at the design and development of novel purification processes in order to intensify and optimize the downstream processing of proteins and biopharmaceuticals, with special emphasis on monoclonal antibodies (mAbs). Several alternatives to the currently established downstream processing platforms of recombinant proteins are being explored, with main focus on aqueous two-phase extraction, nanomagnetic separation and monolithic chromatography, from a nano-scale to industrial scale. Additionally, tailor-made synthetic ligands are being used aiming to improve protein purification, stability and function.