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The research developed in the Nucleic Acid Bioengineering Laboratory is focused on two main areas: i) plasmid vectors and their application in gene therapy or DNA vaccination; and ii) microchips for DNA detection. The specific objectives are to address the scientific/technological challenges associated with plasmid biopharmaceuticals by combining biomolecular engineering studies with bioprocess engineering and to co-develop (with INESC-MN) thin-film microchip and microfluidic platforms for the manipulation/detection of DNA.