Javad Hatami
PhD Candidate
(MIT|Portugal Program)
Background
MSc in Biomedical Engineering, Amirkabir University of Technology, 2009
BSc in Mechanical Engineering, Mazandaran University, 2005
Research Activities
My research is mainly focus in studying the differentiation of umbilical cord blood (UCB) hematopoietic stem/progenitor cells (HSC) into blood platelets. The main idea explored herein is to integrate a high yield HSC expansion stage with an efficient Megakaryocyte differentiation stage and then maturation into blood platelets. I intend to design a system that allows a certain degree of independent optimal conditions for each stage, achieving high yields of platelet production. The ultimate goal of my work is to gain knowledge to be applied towards the development of a bioreactor system able to produce platelets in vitro from stem cells. My research interests are stem cell bioengineering, cell and soft tissue biomechanics, and finite element modeling in bioengineering.
Selected Publications
J. Hatami, P.Z. Andrade, J.M. S. Cabral, C.L. da Silva, F.C. Ferreira,” Developing a co-culture system for effective megakaryo/thrombopoiesis from umbilical cord blood hematopoietic stem/progenitor cells”, Cytotherapy, 2015
A. Poursamar, J. Hatami, A.N. Lehner, C.L. da Silva, F.C. Ferreira, P. Antunes, “Gelatin Porous Scaffolds Fabricated by a Simple Gas Foaming Technique: Characterisation and Cytotoxicity Assessment”, Journal of Materials Science and Engineering: C, 03/2015; 48:63-70
J. Hatami, P.Z. Andrade, D. Bacalhau, F. Cirurgião, F.C. Ferreira, J.M. S. Cabral, C.L. da Silva, ,”Proliferation extent of CD34+ cells as a key parameter to maximize megakaryocytic differentiation of umbilical cord blood-derived hematopoietic stem/progenitor cells in a two-stage culture protocol”, Biotechnology Reports, 2014, DOI: 10.1016/j.btre.2014.07.002.
J. Hatami, M. Tafazzoli-Shadpour, N. Haghighipour, M.A. Shokrgozar, M. Janmaleki, “Influence of Cyclic Stretch on Mechanical Properties of Endothelial Cells”. Experimental Mechanics, (2013) 53:1291-1298.
J. Hatami, M. Janmaleki, M. Tafazoli-Shadpour, M.A. Shokrgozar, N. Haghighipour, “Evaluation of effects of cyclic loading on structural properties of cultured endothelial cells”. Modares Journal of Medical Sciences: Pathobiology, 2010, 12 (4):19-30
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