Sara Badenes

Post-Doctoral Researcher


PhD in Biotechnology, 2010

Graduation in Chemical Engineering, IST, 2005

Research Activities

The potential application of stem cells (both embryonic and adult) in regenerative medicine requires the production of large quantities of these cells. To fulfil these requirements there is a need to develop large-scale bioreaction systems, including the design and optimization of bioreactors for the ex-vivo expansion and controlled differentiation of stem cells. My research focuses on the design, operation and characterization of a stirred suspension bioreactor for the expansion and neural differentiation of human induced pluripotent stem cells on microcarriers that can be scaled-up. The integration of expansion and neural differentiation in a single step is also aimed at reducing processing costs and time.

Selected publications

Badenes, S. M., Fernandes, T. G., Rodrigues, C. A., Diogo, M. M., Cabral, J. S., “Scalable Expansion of Human-Induced Pluripotent Stem Cells in Xeno-Free Microcarriers”, Methods in Molecular Biology, in press DOI: 10.1007/7651_2014_106


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