Carla C.C. R. de Carvalho
Research Scientist
Background
Research Scientist (Ciência 2007), IST , 2008-2013
Post-doctoral fellow, UFZ – Helmholtz Centre
for Environmental Research Leipzig and IST,
2007-February 2008
Post-doctoral fellow, IST, 2004-2006
Ph. D. in Biotechnology, IST, 2003
M. Sc. in Biotechnology (Biochemical Engineering), IST, 1999
Graduation in Chemical Engineering, IST, 1998
Research Activities
Mechanisms of resistance and adaptation of Gram-positive bacterial
cells to toxic compounds (e.g. organic solvents, antibiotics and
antineoplastic agents). Development of micro-reactors to study the
application of the knowledge acquired on bacterial adaptation to
biocatalysis, biotransformation, bioremediation and biomedicine
processes.
Cellular adhesion mechanisms required to the formation of biofilms
and the processes necessary to prevent and destroy biofilms.
Micro-reactor engineering to develop biocatalytic processes using
whole cells of bacteria, in particular Rhodococcus
strains, to produce compounds with potential interest to the food
and pharmaceutical industries.
Development of fluorescence microscopy and image analysis techniques
to monitor biological processes.
Selected Publications
Carla C. C. R. de Carvalho (2012) Adaptation of Rhodococcus erythropolis cells for growth and bioremediation under extreme conditions. Research in Microbiology. 163: 125-136.
Carla C.C.R. de Carvalho, Maria José Caramujo (2012) Lipids of
prokaryotic origin at the base of marine food webs, Marine Drugs
10(12): 2698-2714.
Carla C.C.R. de Carvalho, Maria José Caramujo (2012) Tumour
metastasis as an adaptation of tumour cells to fulfil their
phosphorus requirements. Medical Hypotheses, 78(5): 664-667.
Marco P.C. Marques, Kieran Walshe, Sean Doyle, Pedro Fernandes,
Carla C.C.R. de Carvalho (2012) Anchoring high-throughput screening
methods to scale-up bioproduction of siderophores. Process
Biochemistry, 47, 416-421.
Carla C.C.R. de Carvalho (2011) Enzymatic and whole cell catalysis:
finding new strategies for old processes. Biotechnology Advances.
29(1):75-83.
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