Susana Bernardino

PhD student



MSc in Biotechnology (Biochemical Engineering),

IST, 2000
Graduation in Chemical Engineering, IST, 1996


Research Activities


Semi-synthetic penicillins (e.g. amoxicillin, ampicillin) and cephalosporins (e.g. cephalexin, cefaclor) correspond to 65% of the ever rising worldwide production of antibiotics. Penicillin G acylase (PGA) from E. coli is currently used to catalyze the synthesis of this b-lactam antibiotics. Availability of inexpensive enzyme catalysts with improved specificity, activity, purity and stability is a key issue in the development of successful methodologies for the enzymatic-based production of b-lactam antibiotics which allow for significant cost saving in the production. My research aims to optimize the immobilization of PGA in sol-gel matrices with magnetic properties and apply this new biocatalyst  in cephalexin synthesis.

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